Koumbit.org recently helped TouchTunes.com re-launch their site using Drupal.
The interesting part of this implementation is that all the images that disinguish the pages from one another (e.g. the graphical node titles, the photos of the people at bottom-left and the buttons at the bottom) are actually defined in the nodes themselves even if they are displayed outside of the main content section. Not only does this allow for easy creation and management of pages that look a little less templated, this is accomplished without the site editors having to know anything about HTML/CSS.
Another point worth noting is that this project led to the development of an XHTML compliant "taxonomy ticker" module. This module generates a box (which, in this case, is repositioned into the header using CSS) that scrolls the body text of nodes associated to a particular taxonomic term.
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Koumbit.org is a collective of progressive geeks based in Montreal, Quebec that I have helped found. It is home to a growing number of drupal fans. Not only will we be re-launching our own site very soon using Drupal (it is now a relatively disorganised, French-only, wiki) we are also undertaking a series of initiatives based on this amazing tool. One of the most interesting of these is decisions.gnuvernment.org.